Description
Syn‑Coll is a synthetic peptide compound, also known as palmitoyl tripeptide‑5. It was designed to mimic the activity of thrombospondin‑1 (TSP‑1), a natural extracellular matrix protein that appears to stimulate transforming growth factor‑beta (TGF‑β), a growth factor considered important for maintaining skin integrity and stimulating collagen synthesis.
The short sequence Lys‑Arg‑Phe‑Lys of TSP‑1 is believed responsible for TGF‑β stimulation. Syn‑Coll consists of the sequence Palmitoyl‑Lys‑Val‑Lys, and researchers report it may exert similar actions on TGF‑β. As a result, in animal models and dermal fibroblast cell culture tests, Syn‑Coll may stimulate collagen production — specifically increased production of Type I and Type III collagen by dermal fibroblasts via TGF‑β activity.
Syn‑Coll has been studied in laboratory settings and is generally hypothesized to increase collagen synthesis while also potentially helping prevent collagen degradation. It may inhibit the activity of enzymes like matrix metalloproteinases (MMP1 and MMP3), which are involved in collagen breakdown.
Chemical Makeup
Molecular Formula: C₃₃H₆₅N₅O₅
Molecular Weight: 611.9 g/mol
Other Known Titles: Palmitoyl‑lysyl‑valyl‑lysine, Palmitoyl Tripeptide‑5
Research and Clinical Studies
Syn‑Coll and Collagen Synthesis
Collagen is a major structural protein in the skin’s extracellular matrix. Some studies suggest Syn‑Coll may stimulate collagen production by activating TGF‑β, leading to increased levels of type I and type III collagen in dermal fibroblasts.
Syn‑Coll and Collagen Breakdown
Matrix metalloproteinases (MMPs) are enzymes that can degrade collagen proteins. Syn‑Coll appears to reduce collagen breakdown by potentially inhibiting these enzymes, particularly MMP1 and MMP3, which may support net collagen accumulation.
Syn‑Coll and Anti‑Aging Effects
Some experimental data indicate Syn‑Coll may help reduce the appearance of wrinkles in controlled topical studies. In certain research, formulation with Syn‑Coll showed greater wrinkle reduction and improved skin texture compared with placebo or control groups.
Syn‑Coll peptide is available for research and laboratory purposes only. Please review and adhere to our Terms and Conditions before ordering.
