Description
Synaptosomal‑associated protein 8, or the SNAP‑8 peptide, is a synthetic octapeptide analog of the N‑terminal end of the SNAP‑25 peptide. The peptide is made of eight amino acids and is acetylated at the N‑terminus and amidated at the C‑terminus, resulting in the structure Ac‑Glu‑Glu‑Met‑Gln‑Arg‑Arg‑Ala‑Asp‑NH₂.
Overview
SNAP‑8 was developed to compete with SNAP‑25 protein interactions and bind with vesicle‑associated membrane proteins. SNAP‑25 is a key component in neurotransmitter release, normally interacting with membrane proteins like Synaptotagmin 1 to facilitate fusion of vesicles with the cell membrane and release of neurotransmitter contents.
Molecular docking and experimental models suggest SNAP‑8 may bind to parts of the Synaptotagmin 1 protein responsible for calcium response, potentially destabilizing the SNARE complex that is essential for vesicle fusion. This destabilization could interfere with neurotransmitter release, particularly acetylcholine — a neurotransmitter involved in muscle contraction.
By reducing acetylcholine‑mediated muscle activity, SNAP‑8 is studied in experimental settings for its potential to reduce muscle contractions associated with expression lines and wrinkles in skin models.
Chemical Makeup
Molecular Formula: C₄₁H₇₀N₁₆O₆S
Molecular Weight: 1075.16 g/mol
Other Known Titles: Acetyl Glutamyl Heptapeptide‑3, Synaptosomal‑associated protein 8, Acetyl octapeptide‑3
Research and Clinical Studies
SNAP‑8 has been evaluated in cosmetic‑related studies for its effect on expression lines and skin wrinkles. In a randomized, double‑blind trial, topical peptide formulations containing similar peptides showed reductions in wrinkle appearance over weeks of use.
One study indicated that peptides with mechanisms similar to SNAP‑8 reduced expression line depth and skin roughness compared to control formulations, suggesting potential anti‑wrinkle activity in cosmetic research contexts.
SNAP‑8 peptide is available for research and laboratory purposes only. Please review and adhere to our Terms and Conditions before ordering.
