Description
PE-22-28 Peptide
PE-22-28 is a synthetic derivative of the naturally occurring protein spadin — a peptide fragment originally derived from sortilin, which is abundant in the central nervous system. PE-22-28 corresponds to the 22nd to 28th amino acids of the original spadin sequence and is one of the shortest analogs reported to block the TREK-1 (TWIK-related potassium channel) receptor with potential research relevance. This shorter sequence may exhibit enhanced potency and stability compared to spadin in laboratory settings.
Chemical Makeup
Molecular Formula: C₃₅H₅₅N₁₁O₉
Molecular Weight: 773.89 g/mol
Sequence: GVSWGLR
Research and Experimental Studies
TREK-1 Receptor Interaction
TREK-1 is a two-pore potassium channel found in brain regions such as the prefrontal cortex and hippocampus, areas involved in mood regulation, memory, and learning. Spadin and related analogs including PE-22-28 have been studied as TREK-1 blockers, which may increase neuronal excitability by reducing potassium outflow and thereby influence neural signaling pathways.
Depression and Neurogenesis
Preclinical studies suggest PE-22-28 may have antidepressant-like actions in depression models by promoting hippocampal neurogenesis and synaptogenesis. Research indicates that spadin and its derivatives can increase markers like brain-derived neurotrophic factor (BDNF) and activate transcription factors such as pCREB, which are linked to neuronal growth and plasticity.
Nootropic Potential
Because the TREK-1 channel influences neuronal excitability and neurotransmission, PE-22-28 is also explored in research for nootropic effects, potentially supporting memory formation and synaptic function in controlled laboratory models.
Other Experimental Contexts
TREK-1 channels are also studied for roles in pain perception, anesthesia, and neural protection. By acting on these channels, PE-22-28 helps scientists investigate how modulation of TREK-1 affects neuronal signaling and related pathways.
PE-22-28 peptide is available for research and laboratory purposes only. Please review and adhere to our Terms and Conditions before ordering.
