Description
Palmitoyl Tetrapeptide-7
Palmitoyl Tetrapeptide-7 is a small peptide composed of four amino acids: palmitoyl, glycine, glutamine, and arginine. It is a synthetic peptide analog of the natural matrikine peptide, which is considered to play a role in regulating extracellular matrix (ECM) turnover and related cellular activities in laboratory settings. Initial research indicates that Palmitoyl Tetrapeptide-7 may stimulate synthesis of ECM components such as collagen and elastin, and may inhibit production of pro-inflammatory cytokines. It has also been hypothesized to influence gene expression involved in ECM remodeling, cell proliferation, and inflammation.
Palmitoyl Tetrapeptide-7 may also function by suppressing activity of interleukin-6 (IL-6), a cytokine linked to inflammation and ECM degradation. IL-6 secretion tends to increase with age, potentially leading to ECM breakdown and a loss of tissue structural integrity.
Chemical Makeup
Molecular Formula: C₃₄H₆₂N₈O₇
Molecular Weight: 694.9 g/mol
Other Known Titles: Pal-Gly-Gln-Pro-Arg-OH, N-Palmitoylrigin, Palmitoyl-GQPR, Rigin
Research and Experimental Context
Palmitoyl Tetrapeptide-7 Mechanism of Action
In laboratory studies, Palmitoyl Tetrapeptide-7 has been suggested to potentially inhibit matrix metalloproteinases (MMPs) — enzymes that may degrade ECM proteins during normal tissue turnover — which may help preserve ECM integrity. The peptide may also stimulate production of key ECM components such as laminin IV, laminin V, and collagen VII, which are involved in maintaining the structural scaffolding of tissues.
By potentially enhancing ECM synthesis and decreasing IL-6-mediated inflammation, Palmitoyl Tetrapeptide-7 might contribute to improved tissue resilience in experimental models.
Palmitoyl Tetrapeptide-7 and Skin Structure
Research summaries suggest that in controlled studies, formulations containing Palmitoyl Tetrapeptide-7 may stimulate collagen synthesis and reduce inflammation, possibly helping to support skin texture and reduce the appearance of fine lines in topical research models. Combining Palmitoyl Tetrapeptide-7 with other peptides (e.g., Palmitoyl Oligopeptide in “Matrixyl 3000”) has been explored in preliminary studies for synergistic effects on collagen production and ECM support.
Palmitoyl Tetrapeptide-7 is available for research and laboratory purposes only. Please review and adhere to the site’s Terms and Conditions before ordering.
