Description
MOTS-c (40MG) – Research Peptide
MOTS-c (40MG) is a novel mitochondria-derived peptide composed of 16 amino acids, identified as a mitochondrial open-reading-frame of the 12S rRNA-c. It is expressed in various tissues and plasma, suggesting both cell-specific and hormone-like activity. As one of the few studied mitochondrial-derived peptides (MDPs), alongside Humanin, MOTS-c has gained significant attention in advanced metabolic and cellular research.
This peptide is widely studied for its potential role in activating the AMP-activated protein kinase (AMPK) pathway, a key regulator of cellular energy balance. Under conditions of metabolic stress, MOTS-c is believed to translocate to the cell nucleus and influence gene expression, highlighting its role in mitonuclear communication. It may also function extracellularly as a signaling molecule, often referred to as a “mitokine” or mitochondrial hormone.
Chemical Makeup
Molecular Formula: C101H152N28O22S2
Molecular Weight: 2174.64 g/mol
Other Names: Mitochondrial-derived peptide MOTS-c, Mitochondrial open reading frame of the 12S rRNA-c
Research Applications
Preclinical and laboratory studies suggest MOTS-c may play a role in regulating metabolic homeostasis, cellular energy utilization, and adaptation to metabolic stress. Research indicates it may interact with aging-related pathways, including NAD+ metabolism and sirtuin signaling, and could be influenced by physical activity levels.
In skeletal muscle research, MOTS-c has been studied for its potential to enhance glucose uptake and improve metabolic efficiency through AMPK activation. In fat metabolism studies, it has been associated with modulation of glucose and lipid pathways, possibly influencing insulin sensitivity and energy balance.
Further investigations suggest MOTS-c may impact bone metabolism via the TGF-β/SMAD pathway and may support osteogenic differentiation in laboratory models. Additionally, studies indicate a possible relationship between MOTS-c levels and endothelial function, suggesting relevance in vascular and cellular signaling research.
Emerging research also explores its potential association with cellular aging and longevity, with evidence suggesting that changes in MOTS-c expression may correlate with age-related metabolic function.
Product Specifications
Product Name: MOTS-c
Strength: 40MG
Purity: ≥99%
Form: Lyophilized (freeze-dried) powder
Manufacturing Origin: USA
Quality Control: Independently tested with COA
Key Features
Mitochondria-derived research peptide (MDP)
High-purity, lab-tested formulation
Associated with AMPK pathway and metabolic signaling research
Manufactured under strict laboratory standards
Consistent batch quality with verified testing
Secure and sterile packaging
Important Notice
This product is strictly intended for laboratory research purposes only.
Not for human or animal consumption, medical use, diagnostic use, or therapeutic application.
Handle and store according to standard laboratory safety protocols.
