Description
Researchers have suggested that growth hormone-releasing peptides (GHRPs), growth hormone secretagogues (GSHs), and analogs of growth hormones (hGH) may exhibit potential to promote growth hormone secretion. When combined, they have been suggested by researchers to exert significant action. These include increased fat metabolism, increased lean mass, regulated sleep cycle, and enhanced intestinal and cardiac functioning.
CJC-1295 is a synthetic peptide composed of 29 amino acids. The peptide appears to work by activating the Growth Hormone-Releasing Hormone (GHRH) receptors in the pituitary gland. These receptors are typically activated by the native GHRH. CJC-1295 appears to be a synthetic analog made of the first 29 amino acids from the GHRH sequence, which has additional modifications, including the replacement of four amino acids in its structure and the attachment of a Drug Affinity Complex (DAC) to potentially extend the pharmacokinetics of the peptide.
Ipamorelin is a synthetic pentapeptide and has been categorized by scientists as a growth hormone secretagogue (GHS). It has been posited to function similarly to Growth Hormone Releasing Peptides (GHRPs) and to potentially emulate the natural hunger hormone, ghrelin, particularly its potential to stimulate the release of hGH from the cells in the anterior pituitary gland by activating the Growth Hormone Secretagogue receptors 1 Alpha (GHS-R1a).
Fragment 176-191 peptide, as the name suggests, is a small fragment of the growth hormone (hGH) composed of 15 amino acids. This peptide might target the beta-3 adrenergic receptors (ADRB3), which may potentially induce weight loss downstream by boosting fat burning in adipose tissue cells and possibly promoting thermogenesis in skeletal muscle cells.
Presented together, this blend may potentially trigger a small portion of the pituitary gland, possibly stimulating the release of growth hormones. This blend has been posited by scientists to potentially synergistically enhance and regulate growth hormone concentration and maintain equilibrium levels.
Chemical Makeup
Molecular formula
Fragment 176-191: C78H125N23O23S2
CJC-1295 (Mod GRF 1-29): C152H252N44O42
Ipamorelin: C38H49N9O5
Molecular weight
Fragment 176-191: 1817.12 g/mol
CJC-1295 (Mod GRF 1-29): 3367.9 g/mol
Ipamorelin: 711.8 g/mol
Other known titles
Fragment 176-191: AOD 9604, GH (hGH) lipolytic fragment, Somatostatin (177-191), tyrosyl
CJC-1295: Mod GRF 1-29, CJC-1295 without DAC
Ipamorelin: Ipamorelin Acetate, IPA
Research and Clinical Studies
Fragment 176-191 & CJC-1295 & Ipamorelin Blend, and Growth Hormones
While the fragment 176-191 appears to directly mimic the function of hGH, the peptides CJC-1295 and Ipamorelin appear to exert potential by upregulating the synthesis of hGH itself. For example, CJC-1295 has been suggested to have significant hGH-boosting potential in several phase-1 clinical trials, with reported increases in growth hormone levels compared to placebo in human studies. Ipamorelin has also been suggested to potentially increase hGH synthesis.
Fragment 176-191 & CJC-1295 & Ipamorelin Blend, and Lipolytic Action
A clinical trial conducted on Fragment 176-191 alone suggested substantial reductions in body weight for test subjects presented with this peptide over 12 weeks, indicating potential fat-burning action when used in research settings.
Fragment 176-191 & CJC-1295 & Ipamorelin Blend, and Body Composition
Research indicates that Ipamorelin may influence body weight and composition, potentially increasing overall body weight and fat pad weights via ghrelin receptor activation, whereas CJC-1295 may support lean mass improvements. The blend is theorized to combine these differing mechanisms.
Fragment 176-191 & CJC-1295 & Ipamorelin Blend, and Bone Mineral Content
Some research also suggests that peptides like Ipamorelin may be linked with potential increases in bone mineral content, as seen in animal model studies.
This peptide blend is available for research and laboratory purposes only. Please review and adhere to our Terms and Conditions before ordering.
