Description
CJC-1295 & ipamorelin 5mg/5mg (no DAC)
Ipamorelin and CJC-1295 are both considered to be growth hormone secretagogues. Ipamorelin is a synthetic pentapeptide, and CJC-1295 peptide consists of 29 amino acids. Ipamorelin appears to fall into a category of peptides classified as growth hormone secretagogues (GHSs). These are peptides that are assumed to stimulate the release of growth hormones, however are not considered growth hormone releasing peptides themselves.
On the other hand, CJC-1295 has also been suggested by researchers to stimulate the release of growth hormone, primarily by mimicking the actions of the naturally occurring growth hormone-releasing hormone (GHRH). Both Ipamorelin and CJC-1295 5mg/5mg peptides have been assigned by researchers to this class, studied for similar potential actions and apparently differing only in terms of their half-life and pharmacokinetic profiles.
Overview
CJC-1295 & Ipamorelin 5mg/5mg peptides both are suggested by researchers to augment the levels of growth hormones through a possible triggering of the anterior pituitary gland. Scientists consider that once triggered, growth hormones may be naturally secreted, maintaining levels of growth hormones in the organism. CJC-1295 peptide is a tetrasubstituted version of GHRH 1-29, developed to represent the shortest functional sequence of GHRH. GHRH 1-29 consists of the first 29 amino acids of the native GHRH peptide, and may potentially stimulate growth hormone production in pituitary gland cells, called somatotrophs.
The peptide has four amino acid substitutions in its structure, which scientists suggest may enhance its activity and resistance towards proteolytic enzymes. More specifically, the amino acids which are replaced appear to be the 2nd, 8th, 15th, and 27th amino acids. Owing to these substitutions, the peptide might be able to bind covalently to blood albumin, with trace amounts possibly able to bind to fibrinogen and immunoglobulin G (IgG).
As a result, the apparent half-life of the peptide may increase from 10 mins to 30 mins. CJC-1295 might also be linked with the purported drug affinity complex (DAC) element, which may attach to plasma proteins. In particular, the DAC element in CJC-1295 alludes to the connection of N-epsilon-3-maleimidopropionamide derivative of lysine at the C-terminal end.
Chemical Makeup of CJC-1295 & ipamorelin 5mg/5mg
Molecular Formula:
• CJC-1295: C152H252N44O42
• Ipamorelin: C38H49N9O5
Molecular Weight:
• CJC-1295: 3367.9 g/mol
• Ipamorelin: 711.8 g/mol
Other Known Titles:
• CJC-1295: CJC-1295 NO DAC; Mod GRF 1-29
• Ipamorelin: NNC 26-0161
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