Description
Research indicates that peptides CJC-1295 and GHRP-6 may exert potential action on growth hormone release. When presented as a blend, they may possibly induce synergistic action, stimulating an organism’s synthesis and secretion of growth hormones. This peptide blend may possibly help repair mild injuries associated with muscles and surrounding ligaments.
GHRP-6 peptide is a synthetic six amino acid peptide analog of ghrelin, a naturally occurring peptide that is considered by scientists to stimulate the secretion of growth hormones and help maintain their concentrations. To do so, researchers hypothesize that it may activate what is known as the growth hormone secretagogue receptor (GHS-R1a).
In terms of structure, GHRP-6 does not appear to share any homology with ghrelin despite its affinity to the receptors, but instead it appears to be an opioid analog of the peptide Met-enkephalin. Yet, researchers suggest it lacks the opioid activity which is typically associated with these enkephalins. Thus, GHRP-6 is a synthetic hexapeptide that researchers have classified in the group of growth hormone secretagogues (GHSs).
CJC-1295, also referred to as tetra-substituted GRF (1-29), is a synthetic peptide analog of the naturally occurring growth hormone-releasing hormone (GHRH), which is believed by researchers to trigger the release of growth hormones. It is essentially equivalent to the shortest chain of amino acids that may potentially attach to the GHRH receptors, which are the first 29 amino acids of GHRH.
The key structural distinctions between CJC-1295 and GRF (1-29) are found in four altered amino acids of the original 29 amino acids of GHRH. These modifications involve the 2nd, 8th, 15th, and 27th amino acids, and may potentially enhance the peptide’s resistance to degradation by the enzyme dipeptidyl peptidase-4.
Chemical Makeup
Molecular Formula:
CJC-1295 peptide: C₁₅₂H₂₅₂N₄₄O₄₂
GHRP-6 peptide: C₄₆H₅₆N₁₂O₆
Molecular Weight:
CJC-1295 peptide: 3367.9 g/mol
GHRP-6 peptide: 873.0 g/mol
Other Known Titles:
Growth hormone-releasing hexapeptide
Research and Clinical Studies
CJC-1295 & GHRP-6 Peptide Blend and Growth Hormone Levels
A clinical trial reported that subjects given CJC-1295 & GHRP-6 appeared to have increased growth hormone levels compared to placebo. Growth hormone levels increased gradually and remained elevated after peptide exposure. Another study noted concentration-dependent increases in hormone levels. IGF-I (insulin-like growth factor-1) is considered an anabolic mediator of growth hormone.
CJC-1295 & GHRP-6 Peptide Blend and Hypothyroidism
In a study involving hypothyroid subjects, the peptide blend appeared to increase growth hormone secretion more than the individual peptides alone. Researchers suggested a role for somatostatin modulation in this process.
CJC-1295 & GHRP-6 Peptide Blend and Cellular Repair
Research indicates that GHRP-6 and CJC-1295 may help cellular migration and repair processes in animal models, potentially enhancing migration and recovery in tissues affected by injury.
CJC-1295 & GHRP-6 Peptide Blend and Diabetes-Induced Gastrointestinal Activity
Studies suggest that peptides like GHRP-6 may increase gastric emptying and intestinal transit in diabetic models, potentially counteracting gastrointestinal effects of diabetes.
CJC-1295 & GHRP-6 Peptide Blend and Heart Rate
Preliminary research suggests CJC-1295 analogs may help stabilize heart rate and improve cardiac tissue function following injury, potentially improving cardiac pump capacity.
CJC-1295 & GHRP-6 Peptide Blend and Neuroprotection
Some data indicates GHRP-6 may boost IGF-1 expression in certain brain regions, which could activate pathways related to cell survival in neural tissue.
This peptide blend is available for research and laboratory purposes only. Please review and adhere to our Terms and Conditions before ordering.
