Description
N‑Acetyl Semax is a synthetic polypeptide analogous to a fragment of the adrenocorticotropic hormone (ACTH), specifically ACTH (4‑7) (Met‑Glu‑His‑Phe) combined with a Pro‑Gly‑Pro extension at the C‑terminus. The addition of the C‑terminal Pro‑Gly‑Pro (PGP) sequence and N‑terminal acetylation may enhance the peptide’s stability and its potential to cross the blood‑brain barrier by increasing lipophilicity and reducing enzymatic breakdown.
Overview
N‑Acetyl Semax appears to exhibit potential nootropic (memory and cognition‑related) and neuroprotective characteristics. Research suggests the peptide may influence neurotransmitter systems like serotonin and dopamine pathways, modulate gene expression, and interact with endogenous opioid‑related peptides (enkephalins). These actions are thought to be connected to neuronal function, stress response, mood regulation, and cognitive processes.
Chemical Makeup
Molecular Formula: C₃₇H₅₁N₉O₁₀S
Molecular Weight: 858.97 g/mol
Other known titles: ACTH (4‑7)PGP, HY‑P1146
Research and Clinical Studies
N‑Acetyl Semax and Nootropic Potential
In preclinical research, exposure to Semax peptides in rodent models was associated with increased levels of serotonin metabolites (e.g., 5‑HIAA) in brain regions, which suggests potential modulation of serotonergic activity. Some studies reported enhancements in memory, attention, and locomotor responses following peptide exposure in experimental settings.
N‑Acetyl Semax and Neuroprotection
Certain experimental studies with models of ischemic stroke and neural injury reported that animals given Semax showed improvements in restoring neural activity and electrophysiological patterns compared to controls, suggesting possible neuroprotective effects.
N‑Acetyl Semax and Anxiety/Behavior
Preclinical trials in rodent models have looked at behavioral changes in anxiety‑related settings, where Semax exposure appeared to mitigate stress‑related behaviors and improve learning outcomes after stress or separation conditions.
N‑Acetyl Semax peptide is available for research and laboratory purposes only. Please review and adhere to the site’s Terms and Conditions before ordering.
